indole 3 lactic acid (MedChemExpress)

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MedChemExpress indole 3 lactic acid

Tryptophan–derived metabolites in IMQ-induced psoriasiform dermatitis (PsD). ( A ) Targeted LC–MS/MS of fecal metabolites from IMQ-treated mice and Vanicream-treated controls (Vani). Heat map shows z-scored intensities per sample. ( B ) Rank plot of fecal metabolites ordered by log2(fold-change) (IMQ vs Vani). Orange bars indicate higher values in IMQ; purple bars indicate lower values in IMQ. ( C ) Fecal validation plots for selected indole-related metabolites: indole, indole-3-propionic acid (IPA), <t>indoleacetate,</t> <t>and</t> <t>indole-3-lactic</t> acid (ILA). ( D ) Heat map of serum metabolites measured by targeted LC–MS/MS in the same cohorts. ( E ) Serum validation plots for tryptophan (TRP), IPA, indole-3-acetic acid (IAA), and ILA. Bars indicate group means with individual values overlaid. ( F ) Skin measurements of tryptophan. Top: mouse skin (Vani vs IMQ). Bottom: human skin (healthy controls vs psoriasis lesional skin). ( C, E and F ) data are presented as mean ± SEM. *p < 0.05, **p < 0.01.

Indole 3 Lactic Acid, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/indole+3+lactic+acid/Lactic+acid/pmc13035443-40-5-8
Average 94 stars, based on 3 article reviews

indole 3 lactic acid - by Bioz Stars, 2026-10

94/100 stars

Images

1) Product Images from "Indole-3-Lactic Acid Attenuates IMQ-Induced Psoriasiform Dermatitis in Mice via AhR-Dependent Suppression of IL-17A"

Article Title: Indole-3-Lactic Acid Attenuates IMQ-Induced Psoriasiform Dermatitis in Mice via AhR-Dependent Suppression of IL-17A

Journal: Psoriasis: Targets and Therapy

doi: 10.2147/PTT.S585731

Figure Legend Snippet: Tryptophan–derived metabolites in IMQ-induced psoriasiform dermatitis (PsD). ( A ) Targeted LC–MS/MS of fecal metabolites from IMQ-treated mice and Vanicream-treated controls (Vani). Heat map shows z-scored intensities per sample. ( B ) Rank plot of fecal metabolites ordered by log2(fold-change) (IMQ vs Vani). Orange bars indicate higher values in IMQ; purple bars indicate lower values in IMQ. ( C ) Fecal validation plots for selected indole-related metabolites: indole, indole-3-propionic acid (IPA), indoleacetate, and indole-3-lactic acid (ILA). ( D ) Heat map of serum metabolites measured by targeted LC–MS/MS in the same cohorts. ( E ) Serum validation plots for tryptophan (TRP), IPA, indole-3-acetic acid (IAA), and ILA. Bars indicate group means with individual values overlaid. ( F ) Skin measurements of tryptophan. Top: mouse skin (Vani vs IMQ). Bottom: human skin (healthy controls vs psoriasis lesional skin). ( C, E and F ) data are presented as mean ± SEM. *p < 0.05, **p < 0.01.

Techniques Used: Derivative Assay, Liquid Chromatography with Mass Spectroscopy, Biomarker Discovery

ILA inhibits IL-17A production by γδ T cell in vitro. ( A ) Il17a mRNA in cervical lymph node (cLN) cells after 12 h stimulation with IL-23 (50 ng/mL) + IL-1β (10 ng/mL) (Cyto) in the absence or presence of indole-3-lactic acid (ILA) and/or the AhR antagonist CH-223191 (AhRi). ( B ) Representative intracellular cytokine staining plots showing IL-17A–producing γδ T cells within the CD3⁺ TCRγδ⁺ gate after 24 h under the indicated conditions. ( C ) Quantification of (left) the frequency (%) of IL-17A⁺ γδ T cells, (middle) mean fluorescence intensity (MFI) of IL-17A within IL-17A⁺ γδ T cells, and (right) total fluorescence intensity (TFI) of IL-17A across the γδ T-cell gate (sum signal per sample).Bars show mean ± SEM with individual data points (each dot = one biological replicate). Group comparisons used one-way ANOVA with Šidák post hoc tests; ns, not significant; *, P < 0.05; **, P < 0.01,****p < 0.0001.

Figure Legend Snippet: ILA inhibits IL-17A production by γδ T cell in vitro. ( A ) Il17a mRNA in cervical lymph node (cLN) cells after 12 h stimulation with IL-23 (50 ng/mL) + IL-1β (10 ng/mL) (Cyto) in the absence or presence of indole-3-lactic acid (ILA) and/or the AhR antagonist CH-223191 (AhRi). ( B ) Representative intracellular cytokine staining plots showing IL-17A–producing γδ T cells within the CD3⁺ TCRγδ⁺ gate after 24 h under the indicated conditions. ( C ) Quantification of (left) the frequency (%) of IL-17A⁺ γδ T cells, (middle) mean fluorescence intensity (MFI) of IL-17A within IL-17A⁺ γδ T cells, and (right) total fluorescence intensity (TFI) of IL-17A across the γδ T-cell gate (sum signal per sample).Bars show mean ± SEM with individual data points (each dot = one biological replicate). Group comparisons used one-way ANOVA with Šidák post hoc tests; ns, not significant; *, P < 0.05; **, P < 0.01,****p < 0.0001.

Techniques Used: In Vitro, Staining, Fluorescence

other:

Article Title: Black rice diet alleviates colorectal cancer development through modulating tryptophan metabolism and activating AHR pathway
Article Snippet: Indole (catalog number HY‐W001132, MedChemExpressA) and indole‐3‐lactic acid (catalog number HY‐113099, MedChemExpress) were procured from MedChemExpress.

Incubation:

Article Title: Comprehensive characterization of multi-omics landscapes between gut microbial metabolites and the druggable genome in sepsis
Article Snippet: .. Indole-3-lactic acid (ILA; MCE, USA) at varying concentrations was incubated with fluorescently labeled 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (PFKFB2) (Abcam, Cambridge, UK) for 30 minutes at room temperature. .. The binding interaction between ILA and PFKFB2 was quantified using a Monolith NT.115 instrument (NanoTemper Technologies, München, Germany).

Labeling:

In Vitro:

Article Title: IL4I1⁺ Macrophages and TDO2⁺ Myofibroblasts Drive AhR‐Mediated Immunosuppression and Ferroptosis Resistance in Solid Predominant Lung Adenocarcinoma
Article Snippet: Data processing was performed using SCIEX OS software, and metabolites were annotated with KEGG and HMDB database. .. The list of metabolites used in vitro was as follows: 3‐Indoleacetic acid ( I10008 , Psaitong), 3‐Indolepropionic acid (220027, Sigma‐Aldrich), Indole‐3‐ethanol (W010155, MedChemExpress), 5‐Hydroxytryptophol (W041019, MedChemExpress), Indole‐3‐carboxylic acid (T5984, TargetMol), Indole (I104726, Aladdin), Indole‐3‐lactic acid (HY‐113099, MedChemExpress), Formyl‐N‐acetyl‐5‐methoxykynurenamine (AFMK) ( T41345 , TargetMol), Indole‐3‐carboxaldehyde (T8105, TargetMol), and L‐Kynurenine (S5839, Selleck). ..

Article Title: IL4I1⁺ Macrophages and TDO2⁺ Myofibroblasts Drive AhR-Mediated Immunosuppression and Ferroptosis Resistance in Solid Predominant Lung Adenocarcinoma.
Article Snippet: Data processing was performed using SCIEX OS software, and metabolites were annotated with KEGG and HMDB database. .. The list of metabolites used in vitro was as follows: 3-Indoleacetic acid (I10008, Psaitong), 3-Indolepropionic acid (220027, Sigma-Aldrich), Indole-3-ethanol (W010155, MedChemExpress), 5-Hydroxytryptophol (W041019, MedChemExpress), Indole-3-carboxylic acid (T5984, TargetMol), Indole (I104726, Aladdin), Indole-3-lactic acid (HY-113099, MedChemExpress), Formyl-N-acetyl-5-methoxykynurenamine (AFMK) (T41345, TargetMol), Indole-3-carboxaldehyde (T8105, TargetMol), and LKynurenine (S5839, Selleck). .. Data were acquired in both positive and negative multiple reaction monitoring (MRM)modes, and metabolite identification was based on Novogene’s in-house database.

Review